Recent Publications

Sarikouch S, Haverich A, Pepper J, Pomar JL, Hazekamp M, Padalino M, Stellin G, Meyns B, Laufer G, Andreas M, Hübler M, Schmiady M, Ciubotaru A, Horke A, Cebotari S, Tudorache I; ARISE-Trial-Investigators. Every like is not the same. J Thorac Cardiovasc Surg. 2017 Jun;153(6):1553-1555. The free full text of the article here.

Alexander ME. Finding the next good thing. Reply to the Editor. J Thorac Cardiovasc Surg. 2017 Jun;153(6):1555-1556. The free full text of the article here.

Sarikouch S, Horke A, Tudorache I, Beerbaum P, Westhoff-Bleck M, Boethig D, Repin O, Maniuc L, Ciubotaru A, Haverich A, Cebotari S. Decellularized fresh homografts for pulmonary valve replacement: A decade of clinical experience. Eur J Cardiothorac Surg. 2016 Aug;50(2):281-90. The free full text of the article here.

Tudorache I, Horke A, Cebotari S, Sarikouch S, Boethig D, Breymann T, Beerbaum P, Bertram H, Westhoff-Bleck M, Theodoridis K, Bobylev D, Cheptanaru E, Ciubotaru A, Haverich A. Decellularized aortic homografts for aortic valve and aorta ascendens replacement. Eur J Cardiothorac Surg. 2016 Jul;50(1):89-97. The free full text of the article here.

Ueno T, Ozawa H, Taira M, Kanaya T, Toda K, Kuratani T, Sawa Y. Pulmonary Valve Replacement With Fresh Decellularized Pulmonary Allograft for Pulmonary Regurgitation After Tetralogy of Fallot Repair - First Case Report in Japan. Circ J. 2016 Mar 25;80(4):1041-3. The free full text of the article here.

Sarikouch S, Tudorache I, Cebotari S, Horke A, Hilfiker A, Haverich A. Therapieoption für junge Patienten. Deutsches Ärzteblatt. Jg. 112, Heft 35-36, 2015 Aug 31: A1426-11427. The free full text of the article here.

Boer U, Schridde A, Anssar A, Klingenberg M, Sarikouch S, Dellmann A, Harringer W, Haverich A, Wilhelmi M. The immune response to crosslinked tissue is reduced in decellularized xenogeneic and absent in decellularized allogeneic heart valves. Int J Artif Organs. 2015 Apr;38(4):199-209.

Theodoridis K, Tudorache I, Calistru A, Cebotari S, Meyer T, Sarikouch S, Bara C, Brehm R, Haverich A, Hilfiker A. Successful matrix guided tissue regeneration of decellularized pulmonary heart valve allografts in elderly sheep. Biomaterials. 2015 Jun;52:221-8. The abstract of the article can be found here.

Tudorache I, Horke A, Sarikouch S, Ciubotaru A, Breymann T, Boethig D, Beerbaum P, Bertram H, Westhoff-Bleck M, Meschenmoser L, Cebotari S, Haverich A. Core 6. Catheter-Based and Surgical Interventions - Session Title: Surgical Therapy for Valvular Heart Disease: Abstract 19959: Aortic Valve Replacement with Decellularized Aortic Allografts: First Clinical Results. Circulation. 2014;130:A19959. The abstract of the article can be found here.

Neumann A, Sarikouch S, Breymann T, Cebotari S, Boethig D, Horke A, Beerbaum P, Westhoff-Bleck M, Harald B, Ono M, Tudorache I, Haverich A, Beutel G. Early systemic cellular immune response in children and young adults receiving decellularized fresh allografts for pulmonary valve replacement. Tissue Eng Part A. 2014 Mar;20(5-6):1003-11. The free full text of the article here.

Neumann A, Cebotari S, Tudorache I, Haverich A, Sarikouch S. Heart valve engineering: decellularized allograft matrices in clinical practice. Biomed Tech (Berl). 2013 Oct 1;58(5):453-6. The abstract of the article can be found here.

Cebotari S, Tudorache I, Ciubotaru A, Boethig D, Sarikouch S, Goerler A, Lichtenberg A, Cheptanaru E, Barnaciuc S, Cazacu A, Maliga O, Repin O, Maniuc L, Breymann T, Haverich A. Use of fresh decellularized allografts for pulmonary valve replacement may reduce the reoperation rate in children and young adults: early report. Circulation. 2011 Sep 13;124(11 Suppl):S115-23 The free full text of the article here.

 

Selected Relevant Publications 

Tissue engineering

Cebotari S, Tudorache I, Jaekel T, Hilfiker A, Dorfman S, Ternes W, Haverich A, Lichtenberg A. Detergent decellularization of heart valves for tissue engineering: Toxicological effects of residual detergents on human endothelial cells. Artif Organs. 2010;34:206-210

Baraki H, Tudorache I, Braun M, Hoffler K, Gorler A, Lichtenberg A, Bara C, Calistru A, Brandes G, Hewicker-Trautwein M, Hilfiker A, Haverich A, Cebotari S. Orthotopic replacement of the aortic valve with decellularized allograft in a sheep model. Biomaterials. 2009;30:6240-6246

Lichtenberg A, Cebotari S, Tudorache I, Hilfiker A, Haverich A. Biological scaffolds for heart valve tissue engineering. Methods Mol Med. 2007;140:309-317

Tudorache I, Cebotari S, Sturz G, Kirsch L, Hurschler C, Hilfiker A, Haverich A, Lichtenberg A. Tissue engineering of heart valves: Biomechanical and morphological properties of decellularized heart valves. J Heart Valve Dis. 2007;16:567-573; discussion 574

Cebotari S, Lichtenberg A, Tudorache I, Hilfiker A, Mertsching H, Leyh R, Breymann T, Kallenbach K, Maniuc L, Batrinac A, Repin O, Maliga O, Ciubotaru A, Haverich A. Clinical application of tissue engineered human heart valves using autologous progenitor cells. Circulation. 2006;114:I132-137

Schmidt D, Mol A, Breymann C, Achermann J, Odermatt B, Gössi M, Neuenschwander S, Prêtre R, Genoni M, Zund G, Hoerstrup SP. Living autologous heart valves engineered from human prenatally harvested progenitors. Circulation. 2006 Jul 4;114(1 Suppl):I125-31

Grauss RW, Hazekamp MG, Oppenhuizen F, van Munsteren CJ, Gittenberger-de Groot AC, DeRuiter MC. Histological evaluation of decellularised porcine aortic valves: matrix changes due to different decellularisation methods. Eur J Cardiothorac Surg. 2005 Apr;27(4):566-71

Cebotari S, Mertsching H, Kallenbach K, Kostin S, Repin O, Batrinac A, Clezka C, Ciubotaru A, Haverich A. Construction of Tissue Engineered Human Heart Valves Based on an Acellular Allograft Matrix. Circulation. 2002;106[suppl I]:I-63-I-68

 

Valve replacement for congenital heart defects 

Flameng W, Jashari R, De Visscher G, Mesure L and Meuris B. Calcification of allograft and stentless xenograft valves for right ventricular outflow reconstruction: an experimental study in adolescent sheep. J Thorac Cardiovasc Surg. 2011 Jun;141(6):1513-21

Dave H, Mueggler O, Comber M, Enodien B, Nikolaou G, Bauersfeld U, Jenni R, Bettex D, Prêtre R. Risk factor analysis of 170 single-institutional contegra implantations in pulmonary position. Ann Thorac Surg. 2011 Jan;91(1):195-302; discussion 202

Scherptong RW, Hazekamp MG, Mulder BJ, Wijers O, Swenne CA, van der Wall EE, Schalij MJ, Vliegen HW. Follow-up after pulmonary valve replacement in adults with tetralogy of Fallot: association between QRS duration and outcome. J Am Coll Cardiol. 2010 Oct 26;56(18):1486-92.

Schievano S, Taylor AM, Capelli C, Coats L, Walker F, Lurz P, Nordmeyer J, Wright S, Khambadkone S, Tsang V, Carminati M, Bonhoeffer P. First-in-man implantation of a novel percutaneous valve – A new approach to medical device development. EuroIntervention. 2010;5:745-750

Vida VL, Speggiorin S, Maschietto N, Padalino MA, Milanesi O, Carminati M, Stellin G. Surgical re-utilization of a pulmonary valve graft after failed percutaneous treatment. J Heart Valve Dis. 2010 ;19(2):260-2

Jashari R, Fan Y, Van Hoeck B, Vanderkelen A. European Homograft bank (EHB): 20 Years of Cardiovascular Tissue Banking and collaboration with the Transplant Coordination in Europe.Transplantation Proceedings 2010;42:183-189

Oosterhof T, Hazekamp MG, Mulder BJ. Opportunities in pulmonary valve replacement. Expert Rev Cardiovasc Ther. 2009 Sep;7(9):1117-22. Review 

Breymann T, Blanz U, Wojtalik MA, Daenen W, Hetzer R, Sarris G, Stellin G, Planche C, Tsang V, Weissmann N, Boethig D. European Contegra multicentre study: 7-year results after 165 valved bovine jugular vein graft implantations. Thorac Cardiovasc Surg. 2009 Aug;57(5):257-69

Nordmeyer J, Tsang V, Gaudin R, Lurz P, Frigiola A, Jones A, Schievano S, van Doorn C, Bonhoeffer P, Taylor AM. Quantitative assessment of homograft function one year after insertion into pulmonary position - Impact of in-situ homograft geometry on valve competence. EHJ. 2009;30(17):2147-54

Frigiola A, Tsang V, Bull C, Coats L, Khambadkone S, Derrick G, Mist B, Walker F, van Doorn C, Bonhoeffer P, Taylor A.M. Biventricular response following pulmonary valve replacement for right ventricular outflow tract dysfunction–Is age a predictor of outcome? Circulation. 2008;118:182-190

Kadner A, Raisky O, Degandt A, Tamisier D, Bonnet D, Sidi D, Vouhé PR. The Ross procedure in infants and young children. Ann Thorac Surg 2008 ;85 :803-809

Troost E, Meyns B, Daenen W, Van de Werf F, Gewillig M, Van Deyk K, Moons P, Budts W. Homograft survival after tetralogy of Fallot repair: determinants of accelerated homograft degeneration. Eur Heart J. 2007 Oct;28(20):2503-9

Sekarski N, van Meir H, Rijlaarsdam ME, Schoof PH, Koolbergen DR, Hruda J, von Segesser LK, Meijboom EJ, Hazekamp MG. Right ventricular outflow tract reconstruction with the bovine jugular vein graft: 5 years' experience with 133 patients. Ann Thorac Surg. 2007 Aug;84(2):599-605

Jashari R, Tabaku M, Van Hoeck B, Cochez C, Callant M and Vanderkelen A. Decontamination of heart valve and arterial allografts in the European Homograft Bank (EHB): comparison of two different antibiotic cocktails in low temperature conditions. Cell and Tissue Banking 2007;8:247-255

Ghez O, Tsang V.T, Frigiola A, Coats L, Taylor A, van Doorn C, Bonhoeffer P, de Leval M. Right ventricular outflow tract reconstruction for pulmonary regurgitation after repair of tetralogy of Fallot. Eur J Cardiothorac Surg 2007;31(4):654-658

Dave H, Dodge-Khatami A, Kadner A, Prêtre R. Modified technique for heterotopic implantation of a right ventricular outflow tract conduit. Ann Thorac Surg. 2006 Jun;81(6):2321-3.

Meyns B, Jashari R, Gewillig M, Mertens M, Komarek A, Lesafre E, Budts W, Daenen W Factors influencing the survival of cryopreserved homografts. The second homograft performs as well as the First. Eur J Cardiothorac Surg. 2005 Aug;28(2):211-6; discussion 216

Dave H, Buechel ER, Dodge-Khatami A, Kadner A, Rousson V, Bauersfeld U, Prêtre R. Early insertion of a pulmonary valve for chronic regurgitation helps restoration of ventricular dimensions. Ann Thorac Surg. 2005 Nov;80(5):1615-20; discussion 1620-1.

Buechel ER, Dave H, Kellenberger CJ, Dodge-Khatami A, Pretre R, Berger F, Bauersfeld U. Remodelling of the right ventricle after early pulmonary valve replacement in children with repaired tetralogy of Fallot: assessment by cardiovascular magnetic resonance. Eur Heart J. 2005 Dec;26(24):2721-7.

Oosterhof T, Meijboom FJ, Vliegen HW, Hazekamp MG, Zwinderman AH, Bouma BJ, van Dijk AP, Mulder BJ. Long-term follow-up of homograft function after pulmonary valve replacement in patients with tetralogy of Fallot. Eur Heart J. 2006 Jun;27(12):1478-84. Epub 2006 May 17.

Boudjemline Y, Bonnet D, Abdel Massih T, Agnoletti G, Iserin F, Jaubert F, Sidi D, Vouhé P. Use of bovine jugular vein to reconstruct the right ventricular outflow tract : early results. J Thorac Cardiovasc Surg 2003;126:490-497